Ethanol → Tert-butyl 4-(piperidine-2-carbonyl)piperazine-1-carboxylate

HRID 815310Notes

Reaction equation

HRID 815310 reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[CH2:16][CH2:17][N:18]([C:21](=[O:22])[CH:23]2[N:24]([C:29]([O:30][CH2:31][c:32]3[cH:33][cH:34][cH:35][cH:36][cH:37]3)=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28]2)[CH2:19][CH2:20]1.[CH3:39][CH2:40][OH:41].[CH:1]1=[CH:6][CH:5]=[CH:4][CH2:3][CH2:2]1.[OH2:7]>>[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[N:15]1[CH2:16][CH2:17][N:18]([C:21](=[O:22])[CH:23]2[NH:24][CH2:25][CH2:26][CH2:27][CH2:28]2)[CH2:19][CH2:20]1

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 116051,3-CyclohexadieneHCID 684578424-(1-Benzyloxycarbonylpiperidine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 50986447Tert-butyl 4-(piperidine-2-carbonyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-6be9ccbf02b64f2d9d28f751a081f93d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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