反应详情

[1-(3-Bromo-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (8.408 g, 22.96 mmol) was dissolved in 105 ml 4 N HCl in dioxane. The reaction was stirred for 45 min. After completion volatiles were removed under reduced pressure to yield a white solid. 1H-NMR (360 MHz, DMSO-d6): 9.30 (br, 3H, NH3+), 7.85 (s, 1H), 7.70 (d, 1H), 7.60 (d, 1H), 7.49 (t, 1H), 6.63 (t, 1H, CHF2), 6.03 (br, 1H), 4.05 (m, 2H); MS: 266 [(M+H)+].

1. customAfter completion volatiles were removed under reduced pressure
2. customto yield a white solid