HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → HCID 86650257, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 3-Morpholinone,5-(5-bromo-2-fluorophenyl)-5-(difluoromethyl)- | HCID 66665721 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86650257 | HCID 86650257 | — |
Reaction Steps
A mixture of 7.34 g (22.65 mmol) 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-morpholin-3-one and 5.19 g (12.46 mmol) Lawesson's reagent in 73 ml of THF was refluxed for 1 h. The mixture was concentrated and crystallized from DCM/hexane and recrystallized from EtOH to yield the desired product as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846658B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7d68ee15cf314a5998b56e8d636280a7 |
| Source note | uspto-grants-2014_09 |