反应详情

A mixture of 7.34 g (22.65 mmol) 5-(5-bromo-2-fluoro-phenyl)-5-difluoromethyl-morpholin-3-one and 5.19 g (12.46 mmol) Lawesson's reagent in 73 ml of THF was refluxed for 1 h. The mixture was concentrated and crystallized from DCM/hexane and recrystallized from EtOH to yield the desired product as colorless crystals.

1. temperaturewas refluxed for 1 h
2. concentrationThe mixture was concentrated
3. customcrystallized from DCM/hexane
4. customrecrystallized from EtOH