Bromide ion → 3-Acetyl-1-(4-bromo-2,5-difluorophenyl)-5-methoxypyridazin-4(1H)-one

HRID 815451Notes

Reaction equation

HRID 815451 reaction equation
[Br-:25].[Br:1][c:2]1[cH:3][c:4]([F:24])[c:5](-[n:9]2[n:10][c:11]([C:18](=[O:19])[N:20]([O:21][CH3:22])[CH3:23])[c:12](=[O:17])[c:13]([O:15][CH3:16])[cH:14]2)[cH:6][c:7]1[F:8].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:26][Mg+:27]>>[Br:1][c:2]1[cH:3][c:4]([F:24])[c:5](-[n:9]2[n:10][c:11]([C:18](=[O:19])[CH3:26])[c:12](=[O:17])[c:13]([O:15][CH3:16])[cH:14]2)[cH:6][c:7]1[F:8]

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 580723461-(4-Bromo-2,5-difluorophenyl)-N,5-dimethoxy-N-methyl-4-oxo-1,4-dihydropyridazine-3-carboxamideHCID 178477777HCID 178477777, compound

Product 1

HCID 580723823-Acetyl-1-(4-bromo-2,5-difluorophenyl)-5-methoxypyridazin-4(1H)-one

Sources & evidence

ORD record
ord-9a30a0af1246427586c214b003502882
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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