反应详情

A solution of 598 mg (1.616 mmol) [2-Amino-2-(3-bromo-phenyl)-3,3,3-trifluoro-propoxy]-acetic acid ethyl ester in 5.4 ml toluene and 2.7 ml TFA was heated at reflux temperature for 5 h. The cooled down mixture was evaporated, taken up in EtOAc, washed with 5% aqueous NaHCO3, dried with Na2SO4 and evaporated to give the essentially pure title compound as a colorless solid.

1. temperatureat reflux temperature for 5 h
2. temperatureThe cooled down mixture
3. customwas evaporated
4. washwashed with 5% aqueous NaHCO3
5. dry with materialdried with Na2SO4
6. customevaporated