Dimethylformamide → tert-butyl 4-[2-(hydroxymethyl)-2,3-dihydroindol-1-yl]-2-[4-(2-methylimidazol-1-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

HRID 815790Notes

Reaction equation

HRID 815790 reaction equation
[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][cH:9][c:10]([NH:13][c:14]3[n:15][c:16]([O:31][S:32]([C:33]([F:34])([F:35])[F:36])(=[O:37])=[O:38])[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:11][cH:12]2)[cH:4][cH:5][n:6]1.[NH:39]1[CH:40]([CH2:48][OH:49])[CH2:41][c:42]2[cH:43][cH:44][cH:45][cH:46][c:47]21.[O:50]=[CH:51][N:52]([CH3:53])[CH3:54]>>[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][cH:9][c:10]([NH:13][c:14]3[n:15][c:16]([N:39]4[CH:40]([CH2:48][OH:49])[CH2:41][c:42]5[cH:43][cH:44][cH:45][cH:46][c:47]54)[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:11][cH:12]2)[cH:4][cH:5][n:6]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 27946642,3-dihydro-1H-indol-2-ylmethanolHCID 59333780tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Product 1

HCID 68415418tert-butyl 4-[2-(hydroxymethyl)-2,3-dihydroindol-1-yl]-2-[4-(2-methylimidazol-1-yl)anilino]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

Sources & evidence

ORD record
ord-e962a7884887419d8c5a9af839bf155f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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