Dichloromethane → Methyl 2-fluoromethyl-2-phthalimido-4-pentenoate

HRID 815932Notes

Reaction equation

HRID 815932 reaction equation
[C:19]([c:20]1[c:21]([C:22](=[O:23])[Cl:30])[cH:25][cH:26][cH:27][cH:28]1)([Cl:24])=[O:29].[CH3:12][CH2:13][N:14]([CH2:15][CH3:16])[CH2:17][CH3:18].[Cl:31][CH2:32][Cl:33].[F:1][CH2:2][C:3]([C:4](=[O:5])[O:6][CH3:7])([CH2:8][CH:9]=[CH2:10])[NH2:11]>>[F:1][CH2:2][C:3]([C:4](=[O:5])[O:6][CH3:7])([CH2:8][CH:9]=[CH2:10])[N:11]1[C:19](=[O:29])[c:20]2[c:21]([cH:25][cH:26][cH:27][cH:28]2)[C:22]1=[O:23]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6955Phthaloyl chlorideHCID 8471TriethylamineHCID 20487154Methyl 2-amino-2-(fluoromethyl)pent-4-enoate

Product 1

HCID 20487178Methyl 2-fluoromethyl-2-phthalimido-4-pentenoate

Sources & evidence

ORD record
ord-2a3d90c0047440b48095c8fa1c39d93f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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