反应详情

To a refluxing solution of potassium tert-butylate (1.63 g, 14.52 mmol) in 555 ml t-BuOH was added dropwise a solution of) N-[1-(5-bromo-2-fluoro-phenyl)-1-difluoromethyl-3-hydroxy-propyl]-2-chloro-acetamide (2.72 g, 7.26 mmol) in 45 ml THF over a period of 40 minutes. The reaction mixture was cooled down and quenched with 1N HCl. EtOAc was added and the organic layer was washed with brine, dried with Na2SO4 and evaporated. The crude product was crystallized from DCM/TBME to provide the title compound as white crystals.

1. temperatureThe reaction mixture was cooled down
2. customquenched with 1N HCl
3. additionEtOAc was added
4. washthe organic layer was washed with brine
5. dry with materialdried with Na2SO4
6. customevaporated
7. customThe crude product was crystallized from DCM/TBME