Acetic Acid → N-[4-({2-[(3-isopropylphenyl)amino]-1-methyl-1H-benzimidazol-5-yl}oxy)pyridin-2-yl]-2-(1-methylpiperidin-4-yl)acetamide

HRID 816084Notes

Reaction equation

HRID 816084 reaction equation
[C:42]([BH3-:43])#[N:44].[CH3:38][C:39](=[O:40])[OH:41].[CH3:52][OH:53].[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][c:6]([NH:10][c:11]2[n:12][c:13]3[c:14]([n:15]2[CH3:16])[cH:17][cH:18][c:19]([O:21][c:22]2[cH:23][c:24]([NH:28][C:29]([CH2:30][CH:31]4[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]4)=[O:37])[n:25][cH:26][cH:27]2)[cH:20]3)[cH:7][cH:8][cH:9]1.[Na+:45].[Na+:46].[Na+:47].[O-:48][C:49](=[O:50])[O-:51].[O:54]1[CH2:55][CH2:56][CH2:57][CH2:58]1>>[CH:1]([CH3:2])([CH3:3])[c:4]1[cH:5][c:6]([NH:10][c:11]2[n:12][c:13]3[c:14]([n:15]2[CH3:16])[cH:17][cH:18][c:19]([O:21][c:22]2[cH:23][c:24]([NH:28][C:29]([CH2:30][CH:31]4[CH2:32][CH2:33][N:34]([CH3:38])[CH2:35][CH2:36]4)=[O:37])[n:25][cH:26][cH:27]2)[cH:20]3)[cH:7][cH:8][cH:9]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 887MethanolHCID 923Sodium ion3×HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 498716Cyano-borohydrideHCID 59790190N-(4-(2-(3-isopropylphenylamino)-1-methyl-1H-benzo[d]imidazol-5-yloxy)pyridin-2-yl)-2-(piperidin-4-yl)acetamide

Product 1

HCID 59790284N-[4-({2-[(3-isopropylphenyl)amino]-1-methyl-1H-benzimidazol-5-yl}oxy)pyridin-2-yl]-2-(1-methylpiperidin-4-yl)acetamide

Sources & evidence

ORD record
ord-5069b692f43748d9a6c6c2e7dffd6d51
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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