Borane → (2S,4R)-tert-butyl 4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

HRID 816264Notes

Reaction equation

HRID 816264 reaction equation
[BH3:24].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][CH:14]([O:16][CH2:17][c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[CH2:15]1.[CH2:25]1[O:26][CH2:27][CH2:28][CH2:29]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:10][OH:11])[CH2:13][CH:14]([O:16][CH2:17][c:18]2[cH:19][cH:20][cH:21][cH:22][cH:23]2)[CH2:15]1

Participants

4

Reactant 3

HCID 6331BoraneHCID 8028TetrahydrofuranHCID 41798284-(Benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Product 1

HCID 14821718(2S,4R)-tert-butyl 4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-ff801643b7b04e8395aaecaaa49bf75b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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