Isopropanol → 2-(chloromethyl)-N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine
Reaction equation
[CH:35]([OH:36])([CH3:37])[CH3:38].[Cl:1][c:2]1[n:3][c:4]([CH2:22][Cl:23])[n:5][c:6]2[cH:7][c:8](-[c:12]3[n:13][cH:14][cH:15][cH:16][c:17]3[C:18]([F:19])([F:20])[F:21])[cH:9][cH:10][c:11]12.[F:24][C:25]([c:26]1[cH:27][cH:28][c:29]([NH2:30])[cH:31][cH:32]1)([F:33])[F:34]>>[c:2]1([NH:30][c:29]2[cH:28][cH:27][c:26]([C:25]([F:24])([F:33])[F:34])[cH:32][cH:31]2)[n:3][c:4]([CH2:22][Cl:23])[n:5][c:6]2[cH:7][c:8](-[c:12]3[n:13][cH:14][cH:15][cH:16][c:17]3[C:18]([F:19])([F:20])[F:21])[cH:9][cH:10][c:11]12Participants
4
Sources & evidence
- ORD record
- ord-39e58b7288f04ed4ae42ff43a72e6c1c
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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