Dichloromethane → 2-Methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide

HRID 816430Notes

Reaction equation

[C:1]([CH:2]([CH3:3])[CH3:4])(=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([CH3:26])[c:11]([CH:13]2[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]2)[cH:12]1.[Cl:34][CH2:35][Cl:36].[F:27][C:28]([F:29])([F:30])[C:31]([OH:32])=[O:33]>>[C:1]([CH:2]([CH3:3])[CH3:4])(=[O:5])[NH:6][c:7]1[cH:8][cH:9][c:10]([CH3:26])[c:11]([CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[cH:12]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 16756289Tert-butyl 4-[5-(isobutyrylamino)-2-methylphenyl]1-piperidinecarboxylate

Product 1

HCID 167572542-Methyl-N-[4-methyl-3-(4-piperidinyl)phenyl]propanamide

Sources & evidence

ORD record: ord-e97010151f8548a4893e8778bdfae63f
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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