Hydrochloric Acid → 4-{6-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyridin-3-yl}benzonitrile

HRID 816541Notes

Reaction equation

HRID 816541 reaction equation
[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:24])[n:11][c:12](-[c:14]3[cH:15][cH:16][c:17]4[c:22]([cH:23]3)[CH2:21][NH:20][CH2:19][CH2:18]4)[cH:13]2)[CH2:6][CH2:7]1.[ClH:25].[F:26][c:27]1[cH:28][cH:29][c:30](-[c:33]2[cH:34][cH:35][c:36]([C:37]#[N:38])[cH:39][cH:40]2)[cH:31][n:32]1>>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([c:8]2[n:9][c:10]([NH2:24])[n:11][c:12](-[c:14]3[cH:15][cH:16][c:17]4[c:22]([cH:23]3)[CH2:21][N:20]([c:27]3[cH:28][cH:29][c:30](-[c:33]5[cH:34][cH:35][c:36]([C:37]#[N:38])[cH:39][cH:40]5)[cH:31][n:32]3)[CH2:19][CH2:18]4)[cH:13]2)[CH2:6][CH2:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 231159914-(6-Fluoropyridin-3-yl)benzonitrileHCID 497794384-(4-Methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine

Product 1

HCID 594967184-{6-[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]pyridin-3-yl}benzonitrile

Sources & evidence

ORD record
ord-91d4f76fa2a74b86a28277d8e494c84b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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