Tetrahydrofuran → Tert-butyl 4-(oxetan-3-yl)piperidine-1-carboxylate

HRID 816554Notes

Reaction equation

HRID 816554 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]([CH2:15][OH:16])[CH2:17][OH:18])[CH2:12][CH2:13]1.[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:19][CH2:20][CH2:21][CH2:22][Li:23].[c:24]1([CH3:25])[c:26]([S:27]([Cl:28])(=[O:29])=[O:30])[cH:31][cH:32][cH:33][cH:34]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH:14]2[CH2:15][O:18][CH2:17]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8623o-Toluenesulfonyl chlorideHCID 59605609Tert-butyl 4-(1,3-dihydroxypropan-2-yl)piperidine-1-carboxylateHCID 178418339Butyllithium

Product 1

HCID 67492460Tert-butyl 4-(oxetan-3-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-70483303d5454ba9ad15604152246238
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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