Ethylamine tetrahydrofuran → 6-({5-[2-(ethylamino)ethoxy]pyridin-2-yl}oxy)-N-(3-methyl-1,2,4-thiadiazol-5-yl)quinazoline-4-amine
Reaction equation
C(O[CH:4](OCC)[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:24][C:25]2[S:29][N:28]=[C:27]([CH3:30])[N:26]=2)=[N:11][CH:12]=1)C.[CH2:34]([NH2:36])[CH3:35].O1CCCC1>>[CH2:34]([NH:36][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[N:20]=[CH:19][N:18]=[C:17]3[NH:24][C:25]2[S:29][N:28]=[C:27]([CH3:30])[N:26]=2)=[N:11][CH:12]=1)[CH3:35]Participants
3
Procedure
Using 6-{[5-(2,2-diethoxyethoxy)pyridin-2-yl]oxy}-N-(3-methyl-1,2,4-thiadiazol-5-yl)quinazoline-4-amine obtained in Example 47 and 2 M ethylamine/tetrahydrofuran solution, and in the same manner as in Example 47 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (24 mg) was obtained as a yellow solid.
Sources & evidence
- ORD record
- ord-a165521f160e4057b445874cde79cf67
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846700B2
Reaction notes
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