Phenol → N-(3-chlorophenyl)-5-(phenoxymethyl)-4-(trifluoromethyl)pyrimidin-2-amine

HRID 816812Notes

Reaction equation

HRID 816812 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][c:12]([CH2:19][OH:20])[c:13]([C:15]([F:16])([F:17])[F:18])[n:14]2)[cH:5][cH:6][cH:7]1.[Cl:59][CH2:60][Cl:61].[O:47]=[C:48]([O:49][CH2:50][CH3:51])[N:52]=[N:53][C:54]([O:55][CH2:56][CH3:57])=[O:58].[OH:21][c:22]1[cH:23][cH:24][cH:25][cH:26][cH:27]1.[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1>>[Cl:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][c:12]([CH2:19][O:20][c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[c:13]([C:15]([F:16])([F:17])[F:18])[n:14]2)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 996PhenolHCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 58168920[2-(3-Chlorophenylamino)-4-trifluoromethyl-pyrimidin-5-yl]-methanol

Product 1

HCID 58168952N-(3-chlorophenyl)-5-(phenoxymethyl)-4-(trifluoromethyl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-8823d7003a5e4232b9ee9dc7cea46b94
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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