Trifluoroacetic acid → Gandotinib

HRID 817098Notes

Reaction equation

[Cl:1][c:2]1[cH:3][c:4]([F:42])[c:5]([CH2:6][c:7]2[c:8]([CH3:39])[n:9][c:10]3[n:11]2[n:12][c:13]([NH:23][c:24]2[n:25][n:26]([CH2:30][c:31]4[cH:32][cH:33][c:34]([O:35][CH3:36])[cH:37][cH:38]4)[c:27]([CH3:29])[cH:28]2)[cH:14][c:15]3[CH2:16][N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[cH:40][cH:41]1.[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[Cl:1][c:2]1[cH:3][c:4]([F:42])[c:5]([CH2:6][c:7]2[c:8]([CH3:39])[n:9][c:10]3[n:11]2[n:12][c:13]([NH:23][c:24]2[n:25][nH:26][c:27]([CH3:29])[cH:28]2)[cH:14][c:15]3[CH2:16][N:17]2[CH2:18][CH2:19][O:20][CH2:21][CH2:22]2)[cH:40][cH:41]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 674350193-(4-Chloro-2-fluorobenzyl)-N-(1-(4-methoxybenzyl)-5-methyl-1H-pyrazol-3-yl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Product 1

HCID 46213929Gandotinib

Sources & evidence

ORD record: ord-d59c91cf719a4aa38510d211b70e252a
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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