Dichloromethane → Ethyl 4-(piperazin-1-yl)benzoate

HRID 817128Notes

Reaction equation

HRID 817128 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:23][cH:24]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:32][CH2:33][Cl:34].[F:25][C:26]([F:27])([F:28])[C:29]([OH:30])=[O:31]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:23][cH:24]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 11709764tert-Butyl 4-(4-(ethoxycarbonyl)phenyl)piperazine-1-carboxylate

Product 1

HCID 2761178Ethyl 4-(piperazin-1-yl)benzoate

Sources & evidence

ORD record
ord-339e3482c5044a93b4931ff967282965
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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