Benzenamine, 4-(4-morpholinyl)- → HCID 59491480, compound

HRID 81715Notes

Reaction equation

HRID 81715 reaction equation
Cl[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH:5]=[CH:4][N:3]=1.[O:19]1[CH2:24][CH2:23][N:22]([C:25]2[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=2)[CH2:21][CH2:20]1>>[O:19]1[CH2:20][CH2:21][N:22]([C:25]2[CH:26]=[CH:27][C:28]([NH:29][C:2]3[N:7]=[C:6]([S:8][C:9]4[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=4)[C:12]([O:14][CH3:15])=[O:13])[CH:5]=[CH:4][N:3]=3)=[CH:30][CH:31]=2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 86645571Methyl 3-(2-chloropyrimidin-4-ylthio)benzoate

Product 1

HCID 59491480HCID 59491480, compoundYield 87%

Procedure

In a procedure analogous to Example 8, reaction of methyl 3-(2-chloropyrimidin-4-ylthio)benzoate (310 mg, 1.84 mmol) and 4-morpholinoaniline (394 mg, 2.21 mmol) furnished the product (410 mg, 87%).

Sources & evidence

ORD record
ord-0c8824d4685e4f549b0050f44984760c
Source dataset
uspto-grants-2014_09
Patent number
US08846704B2

Reaction notes

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