Methanol → 9-Bromo-6-(4-methyl-1piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

HRID 817203Notes

Reaction equation

HRID 817203 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N:18]2[CH2:19][CH2:20][c:21]3[cH:22][cH:23][cH:24][cH:25][c:26]32)[c:6]([NH:8][C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)[cH:7]1.[CH3:27][OH:28].[P:29]([Cl:30])([Cl:31])([Cl:32])=[O:33]>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:7]1)[N:8]=[C:9]([N:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]1)[c:25]1[cH:24][cH:23][cH:22][c:21]3[c:26]1[N:18]2[CH2:19][CH2:20]3

Participants

4

Reactant 3

HCID 887MethanolHCID 24813Phosphorus oxychlorideHCID 13823352N-[2-(indolin-1-yl)-5-bromophenyl]-4-methyl-1-piperazinecarboxamide

Product 1

HCID 138232899-Bromo-6-(4-methyl-1piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

Sources & evidence

ORD record
ord-8f33efe459c04d7baa25d8d970c80d3c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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