Tetrahydrofuran → Tert-butyl 3-bromo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoate

HRID 817222Notes

Reaction equation

HRID 817222 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([C:15]([C:16]([F:17])([F:18])[F:19])=[O:20])[cH:14]1.[CH2:30]([N+:31]([CH2:32][CH2:33][CH2:34][CH3:35])([CH2:36][CH2:37][CH2:38][CH3:39])[CH2:40][CH2:41][CH2:42][CH3:43])[CH2:44][CH2:45][CH3:46].[CH2:47]1[O:48][CH2:49][CH2:50][CH2:51]1.[F-:29].[F:21][C:22]([F:23])([F:24])[Si:25]([CH3:26])([CH3:27])[CH3:28]>>[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[cH:12][c:13]([C:15]([C:16]([F:17])([F:18])[F:19])([OH:20])[C:22]([F:21])([F:23])[F:24])[cH:14]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 68496903tert-Butyl 3-bromo-5-(trifluoroacetyl)benzoate

Product 1

HCID 86646752Tert-butyl 3-bromo-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzoate

Sources & evidence

ORD record
ord-493f5365c40a41228379c531341c3877
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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