Diisopropylcarbodiimide → 3-Butyl-4-[4-cyclohexyloxy-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-6-(1-methyl-piperidin-4-yloxy)-pyridazine

HRID 817387Notes

Reaction equation

HRID 817387 reaction equation
[CH2:1]([CH2:2][CH2:3][CH3:4])[c:5]1[n:6][n:7][c:8]([O:32][CH:33]2[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]2)[cH:9][c:10]1-[c:11]1[cH:12][cH:13][c:14]([O:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[c:15]([C:16](=[O:17])[NH:18][C:19]([CH2:20][OH:21])([CH3:22])[CH3:23])[cH:24]1.[CH:40]([N:41]=[C:42]=[N:43][CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cu+2:57].[F:49][C:50]([F:51])([F:52])[S:53]([O-:54])(=[O:55])=[O:56].[F:58][C:59]([F:60])([F:61])[S:62]([O-:63])(=[O:64])=[O:65].[O:66]1[CH2:67][CH2:68][O:69][CH2:70][CH2:71]1>>[CH2:1]([CH2:2][CH2:3][CH3:4])[c:5]1[n:6][n:7][c:8]([O:32][CH:33]2[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]2)[cH:9][c:10]1-[c:11]1[cH:12][cH:13][c:14]([O:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[c:15]([C:16]2=[N:18][C:19]([CH3:22])([CH3:23])[CH2:20][O:17]2)[cH:24]1

Participants

6

Reactant 5

HCID 12734DiisopropylcarbodiimideHCID 27099Cupric cationHCID 312751,4-DioxaneHCID 2758875Trifluoromethanesulfonate2×HCID 673756195-[3-butyl-6-(1-methyl-piperidin-4-yloxy)-pyridazin-4-yl]-2-cyclohexyloxy-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

Product 1

HCID 584383623-Butyl-4-[4-cyclohexyloxy-3-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-6-(1-methyl-piperidin-4-yloxy)-pyridazine

Sources & evidence

ORD record
ord-e0c8bc3ba7b044929d6b27aa468f1d1c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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