Methanol → N-{4-[2-(1-Hydroxyethyl)-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl}propanamide

HRID 817621Notes

Reaction equation

HRID 817621 reaction equation
[C:3](=[O:4])([c:5]1[cH:6][cH:7][cH:8][cH:9][cH:10]1)[O:11][CH:12]([CH3:13])[c:14]1[s:15][c:16](-[c:26]2[cH:27][c:28]([NH:32][C:33]([CH2:34][CH3:35])=[O:36])[n:29][cH:30][cH:31]2)[c:17](-[c:19]2[cH:20][c:21]([CH3:25])[cH:22][cH:23][cH:24]2)[n:18]1.[CH3:37][OH:38].[Na+:2].[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[OH-:1]>>[OH:11][CH:12]([CH3:13])[c:14]1[s:15][c:16](-[c:26]2[cH:27][c:28]([NH:32][C:33]([CH2:34][CH3:35])=[O:36])[n:29][cH:30][cH:31]2)[c:17](-[c:19]2[cH:20][c:21]([CH3:25])[cH:22][cH:23][cH:24]2)[n:18]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 534280501-[4-(3-Methylphenyl)-5-(2-propanamidopyridin-4-yl)-1,3-thiazol-2-yl]ethyl benzoate

Product 1

HCID 53432117N-{4-[2-(1-Hydroxyethyl)-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl}propanamide

Sources & evidence

ORD record
ord-3c99e7f940f84101926486edbcb30693
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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