Dichloromethane → Ethyl 3-(benzyloxy)-9-(2-(methylthio)ethyl)-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxylate

HRID 817891Notes

Reaction equation

HRID 817891 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[n:11][c:12]([CH:16]([CH2:17][CH2:18][S:19][CH3:20])[O:21][CH2:22][CH2:23][OH:24])[nH:13][c:14]1=[O:15].[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[Cl:37][CH2:38][Cl:39]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([C:25](=[O:26])[O:27][CH2:28][CH3:29])[n:11][c:12]2[n:13]([c:14]1=[O:15])[CH2:23][CH2:22][O:21][CH:16]2[CH2:17][CH2:18][S:19][CH3:20]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 135848642Ethyl 5-(benzyloxy)-2-(1-(2-hydroxyethoxy)-3-(methylthio)propyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylate

Product 1

HCID 21069951Ethyl 3-(benzyloxy)-9-(2-(methylthio)ethyl)-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxylate

Sources & evidence

ORD record
ord-6b660cb4907c4f0b9956642f6b2f4c67
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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