Sodium ion → 3-[(2,6-Dichloro-4-phenylmethoxyphenyl)methyl]-1-(4-methoxycyclohexyl)pyrrolidin-2-one

HRID 817903Notes

Reaction equation

HRID 817903 reaction equation
[CH2:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[O:10][c:11]1[cH:12][c:13]([Cl:32])[c:14]([CH2:15][CH:16]2[C:17](=[O:28])[N:18]([CH:21]3[CH2:22][CH2:23][CH:24]([OH:27])[CH2:25][CH2:26]3)[CH2:19][CH2:20]2)[c:29]([Cl:31])[cH:30]1.[CH3:35][N:36]([CH3:37])[CH:38]=[O:39].[H-:1].[I:33][CH3:34].[Na+:2]>>[CH2:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[O:10][c:11]1[cH:12][c:13]([Cl:32])[c:14]([CH2:15][CH:16]2[C:17](=[O:28])[N:18]([CH:21]3[CH2:22][CH2:23][CH:24]([O:27][CH3:34])[CH2:25][CH2:26]3)[CH2:19][CH2:20]2)[c:29]([Cl:31])[cH:30]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 6228DimethylformamideHCID 6328Methyl iodideHCID 166653HydrideHCID 592994723-(4-Benzyloxy-2,6-dichloro-benzyl)-1-(cis-4-hydroxy-cyclohexyl)-pyrrolidin-2-one

Product 1

HCID 666218313-[(2,6-Dichloro-4-phenylmethoxyphenyl)methyl]-1-(4-methoxycyclohexyl)pyrrolidin-2-one

Sources & evidence

ORD record
ord-4d1d86bedd074f5b8929dde1947f8271
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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