Ethyl Acetoacetate → 5-Isopropyl-6-methoxy-3-methyl-1H-indole-2-carboxylic acid ethyl ester

Temperature

70 °C

4-Isopropyl-3-methoxy-phenylamine HCl salt (3.1 g, 19 mmol) was cooled to −5 C (Ice/Methanol bath), and a mixture of 8 ml water and 5 ml concentrated. HCl was added dropwise. The reaction mixture was stirred for five minutes, and sodium nitrite (1.42 g, 21 mmol) dissolved in 3 ml water was added dropwise over 10 minutes. The reaction mixture was stirred for 45 min, then sodium acetate (1.3 g, 16 mmol) was added. In a separate flask, to a stirring mixture of ethyl alpha-acetoacetate (3.26 g, 21 mmol) in 15 ml absolute ethanol was added KOH (1.2 g, 21 mmol) dissolved in 3 ml water and then added ice (10 g). This mixture was added to the diazonium salt, and the reaction mixture was stirred at zero degrees C. for 3.5 hours. The reaction mixture was stored at −10 C for 16 hours, then extracted with EtOAC. The combined organic layers were washed with brine, dried over magnesium sulfate, and concentrated under reduced pressure to a liquid residue. In a separate flask, mixed 100 ml EtOH was mixed slowly with 22 ml acetyl chloride, with cooling in an ice bath. The EtOH/acetyl chloride solution was heated to 70 degrees C., and added the residue was added via pipette over 10 min. The reaction mixture was heated to reflux for 2.5 hours, cooled, evaporated under reduced pressure to give a slurry; diluted with water (100 ml) and filtered. The solid was washed with water. The solid was triturated with hexanes to give 5-Isopropyl-6-methoxy-3-methyl-1H-indole-2-carboxylic acid ethyl ester (1.7 g, 34%) as a solid.

1. concentrationconcentrated
2. additionHCl was added dropwise
3. additionwas added dropwise over 10 minutes
4. stirringThe reaction mixture was stirred for 45 min
5. stirringthe reaction mixture was stirred at zero degrees C
6. waitfor 3.5 hours
7. waitThe reaction mixture was stored at −10 C for 16 hours
8. extractionextracted with EtOAC
9. washThe combined organic layers were washed with brine
10. dry with materialdried over magnesium sulfate
11. concentrationconcentrated under reduced pressure to a liquid residue
12. additionIn a separate flask, mixed 100 ml EtOH
13. additionwas mixed slowly with 22 ml acetyl chloride
14. temperaturewith cooling in an ice bath
15. addition, and added the residue
16. additionwas added via pipette over 10 min
17. temperatureThe reaction mixture was heated
18. temperatureto reflux for 2.5 hours
19. temperaturecooled
20. customevaporated under reduced pressure
21. customto give a slurry
22. filtrationfiltered
23. washThe solid was washed with water
24. customThe solid was triturated with hexanes

ORD record

ord-0b2381b4fa7348b2b7c3952b47abf85d

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08846705B2