Chloride → [6-(2-Methoxyphenyl)-1-(oxan-4-ylmethyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:18](=[O:19])[CH:20]3[C:21]([CH3:25])([CH3:26])[C:22]3([CH3:23])[CH3:24])[cH:7][n:8]([CH2:11][CH:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:9]2[cH:10]1.[C:68](=[O:69])([O-:70])[O-:71].[CH3:27][O:28][c:29]1[c:30]([B:35]([OH:36])[OH:37])[cH:31][cH:32][cH:33][cH:34]1.[CH3:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1.[CH:39]([c:40]1[cH:41][cH:42][cH:43][c:44]([CH:45]([CH3:46])[CH3:47])[c:48]1-[n+:49]1[cH:50][cH:51][n:52](-[c:53]2[c:54]([CH:55]([CH3:56])[CH3:57])[cH:58][cH:59][cH:60][c:61]2[CH:62]([CH3:63])[CH3:64])[cH:65]1)([CH3:66])[CH3:67].[Cl-:38].[Na+:72].[Na+:73].[O:101]=[C:102]([CH:103]=[CH:104][c:105]1[cH:106][cH:107][cH:108][cH:109][cH:110]1)[CH:111]=[CH:112][c:113]1[cH:114][cH:115][cH:116][cH:117][cH:118]1.[O:119]=[C:120]([CH:121]=[CH:122][c:123]1[cH:124][cH:125][cH:126][cH:127][cH:128]1)[CH:129]=[CH:130][c:131]1[cH:132][cH:133][cH:134][cH:135][cH:136]1.[O:83]=[C:84]([CH:85]=[CH:86][c:87]1[cH:88][cH:89][cH:90][cH:91][cH:92]1)[CH:93]=[CH:94][c:95]1[cH:96][cH:97][cH:98][cH:99][cH:100]1.[Pd:81].[Pd:82]>>[c:2]1(-[c:30]2[c:29]([O:28][CH3:27])[cH:34][cH:33][cH:32][cH:31]2)[cH:3][cH:4][c:5]2[c:6]([C:18](=[O:19])[CH:20]3[C:21]([CH3:25])([CH3:26])[C:22]3([CH3:23])[CH3:24])[cH:7][n:8]([CH2:11][CH:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:9]2[cH:10]1Participants
10
Reactant 9
HCID 312Chloride
HCID 923Sodium ion2×
HCID 1140Toluene
HCID 19660Carbonate Ion
HCID 23938Palladium2×
HCID 95417Dibenzylidene acetone3×
HCID 27339582-Methoxyphenylboronic acid
HCID 27349141,3-Bis[2,6-di(propan-2-yl)phenyl]imidazol-1-ium
HCID 247684926-bromo-1-(oxan-4-ylmethyl)-3-[(2,2,3,3-tetramethylcyclopropyl)carbonyl]-1H-indoleProduct 1
Sources & evidence
- ORD record
- ord-550b02171a964e7b81523885efc349e3
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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