Imidazole → 5-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

HRID 818986Notes

Reaction equation

HRID 818986 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[Cu:30].[Cu:31][I:32].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]([C:16]#[N:17])[c:11](=[O:15])[nH:12][c:13]2[CH3:14])[cH:6][cH:7]1.[K+:27].[K+:28].[OH2:29].[nH:18]1[cH:19][n:20][cH:21][cH:22]1>>[c:2]1(-[n:18]2[cH:19][n:20][cH:21][cH:22]2)[cH:3][cH:4][c:5](-[c:8]2[cH:9][c:10]([C:16]#[N:17])[c:11](=[O:15])[nH:12][c:13]2[CH3:14])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 795ImidazoleHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 23978CopperHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 202385991,2-Dihydro-5-(4-fluorophenyl)-6-methyl-2-oxo-3-pyridinecarbonitrile

Product 1

HCID 104461365-(4-Imidazol-1-yl-phenyl)-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile

Sources & evidence

ORD record
ord-6bc2612d84a948f0b16347e54c7a35e9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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