Sodium ion → 3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide

HRID 819015Notes

Reaction equation

HRID 819015 reaction equation
[Cl:51][CH2:52][Cl:53].[F:1][c:2]1[c:3]([C:22](=[O:23])[NH:24][CH2:25][C:26]2([c:39]3[cH:40][cH:41][cH:42][cH:43][cH:44]3)[CH2:27][CH2:28][N:29]([C:32]([O:33][C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[CH2:30][CH2:31]2)[n:4][cH:5][cH:6][c:7]1[S:8][c:9]1[cH:10][n:11][c:12]([NH:14][c:15]2[n:16][cH:17][cH:18][c:19]([CH3:21])[cH:20]2)[s:13]1.[F:54][C:55]([F:56])([F:57])[C:58]([OH:59])=[O:60].[Na+:45].[Na+:46].[O-:47][C:48](=[O:49])[O-:50]>>[F:1][c:2]1[c:3]([C:22](=[O:23])[NH:24][CH2:25][C:26]2([c:39]3[cH:40][cH:41][cH:42][cH:43][cH:44]3)[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[n:4][cH:5][cH:6][c:7]1[S:8][c:9]1[cH:10][n:11][c:12]([NH:14][c:15]2[n:16][cH:17][cH:18][c:19]([CH3:21])[cH:20]2)[s:13]1

Participants

6

Reactant 5

HCID 923Sodium ion2×HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 19660Carbonate IonHCID 25033034Tert-butyl 4-[[[3-fluoro-4-[[2-[(4-methyl-2-pyridinyl)amino]-1,3-thiazol-5-yl]sulfanyl]pyridine-2-carbonyl]amino]methyl]-4-phenylpiperidine-1-carboxylate

Product 1

HCID 250328563-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)-N-((4-phenylpiperidin-4-yl)methyl)picolinamide

Sources & evidence

ORD record
ord-4a0cd8babab34137816d9cb385163f1e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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