Tetrahydrofuran → 2-tert-butyl 4-methyl (2RS,4RS,5SR)-1-{2-[3-(3-(methoxycarbonylmethylthio)phenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate

HRID 819281Notes

Reaction equation

HRID 819281 reaction equation
[N:1](=[C:2]=[O:3])[c:4]1[cH:5][c:6]([S:10][CH2:11][C:12](=[O:13])[O:14][CH3:15])[cH:7][cH:8][cH:9]1.[NH2:16][CH2:17][C:18](=[O:19])[N:20]1[CH:21]([C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:22][CH:23]([C:31](=[O:32])[O:33][CH3:34])[CH:24]1[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1.[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[NH:1]([C:2](=[O:3])[NH:16][CH2:17][C:18](=[O:19])[N:20]1[CH:21]([C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:22][CH:23]([C:31](=[O:32])[O:33][CH3:34])[CH:24]1[c:25]1[cH:26][cH:27][cH:28][cH:29][cH:30]1)[c:4]1[cH:5][c:6]([S:10][CH2:11][C:12](=[O:13])[O:14][CH3:15])[cH:7][cH:8][cH:9]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 19709517Methyl 2-(3-isocyanatophenyl)sulfanylacetateHCID 867519112-O-tert-butyl 4-O-methyl 1-(2-aminoacetyl)-5-phenylpyrrolidine-2,4-dicarboxylate

Product 1

HCID 867519102-tert-butyl 4-methyl (2RS,4RS,5SR)-1-{2-[3-(3-(methoxycarbonylmethylthio)phenyl)ureido]acetyl}-5-phenylpyrrolidine-2,4-dicarboxylate

Sources & evidence

ORD record
ord-5553f8a95b054f1ab68e1feb66638bfd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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