Dichloromethane → tert-Butyl 4-(((6-methoxy-4-oxo-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

HRID 819384Notes

Reaction equation

HRID 819384 reaction equation
[C:42]([CH3:43])([CH3:44])([CH3:45])[O:46][C:47](=[O:48])[N:49]1[CH2:50][CH2:51][CH:52]([CH2:55][OH:56])[CH2:53][CH2:54]1.[CH2:69]([Cl:70])[Cl:71].[O:57]=[C:58]([O:59][CH2:60][CH3:61])[N:62]=[N:63][C:64]([O:65][CH2:66][CH3:67])=[O:68].[OH:20][c:21]1[c:22]([O:40][CH3:41])[cH:23][c:24]2[c:25](=[O:39])[n:26]([CH2:31][O:32][C:33]([C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[cH:27][n:28][c:29]2[cH:30]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[O:20]([c:21]1[c:22]([O:40][CH3:41])[cH:23][c:24]2[c:25](=[O:39])[n:26]([CH2:31][O:32][C:33]([C:34]([CH3:35])([CH3:36])[CH3:37])=[O:38])[cH:27][n:28][c:29]2[cH:30]1)[CH2:55][CH:52]1[CH2:51][CH2:50][N:49]([C:47]([O:46][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:48])[CH2:54][CH2:53]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 10804576(7-Hydroxy-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl pivalate

Product 1

HCID 11733854tert-Butyl 4-(((6-methoxy-4-oxo-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-20f70aa828124d66ba14ee5fd16f168b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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