HCID 44556334, compound → HCID 67076225, compound

Participants

Reaction Steps

To a solution of 8-{[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methoxyphenyl]amino}-N-(2,6-diethylphenyl)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (300 mg, 0.48 mmol) in 6 ml of dry THF, 800 μl of commercial TBAF solution in THF were added. The mixture was stirred at room temperature for 1 h and the to solvent removed in vacuo. The crude was washed with water, extracted with ethyl acetate, dried on anhydrous Na2SO4 and evaporated to dryness affording the title compound in 85% yield.

Provenance & Evidence