HRID81965

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc(CO[Si](C)(C)C(C)(C)C)cc3OC)nc1-2

HCID44556334

未命名化合物

PRODUCTS

生成物

结构：CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc(CO)cc3OC)nc1-2

HCID67076225

未命名化合物

收率 85%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

溶剂HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

PROCEDURE

实验过程

To a solution of 8-{[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methoxyphenyl]amino}-N-(2,6-diethylphenyl)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (300 mg, 0.48 mmol) in 6 ml of dry THF, 800 μl of commercial TBAF solution in THF were added. The mixture was stirred at room temperature for 1 h and the to solvent removed in vacuo. The crude was washed with water, extracted with ethyl acetate, dried on anhydrous Na2SO4 and evaporated to dryness affording the title compound in 85% yield.

WORKUP

后处理

customthe to solvent removed in vacuo
washThe crude was washed with water
extractionextracted with ethyl acetate
dry with materialdried on anhydrous Na2SO4
customevaporated to dryness

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07cc5a5b34da4961b9d35a5c5d165232
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846701B2
来源说明: uspto-grants-2014_09

反应 SMILES

[Si]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16][C:17]2[N:26]=[CH:25][C:24]3[CH2:23][CH2:22][C:21]4[C:27]([C:31]([NH:33][C:34]5[C:39]([CH2:40][CH3:41])=[CH:38][CH:37]=[CH:36][C:35]=5[CH2:42][CH3:43])=[O:32])=[N:28][N:29]([CH3:30])[C:20]=4[C:19]=3[N:18]=2)=[C:12]([O:44][CH3:45])[CH:11]=1)(C(C)(C)C)(C)C>C1COCC1.CCCC[N+](CCCC)(CCCC)CCCC.[F-]>[CH2:40]([C:39]1[CH:38]=[CH:37][CH:36]=[C:35]([CH2:42][CH3:43])[C:34]=1[NH:33][C:31]([C:27]1[C:21]2[CH2:22][CH2:23][C:24]3[CH:25]=[N:26][C:17]([NH:16][C:13]4[CH:14]=[CH:15][C:10]([CH2:9][OH:8])=[CH:11][C:12]=4[O:44][CH3:45])=[N:18][C:19]=3[C:20]=2[N:29]([CH3:30])[N:28]=1)=[O:32])[CH3:41]