HRID81966

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1cccc(CC)c1NC(=O)c1nn(C)c2c1CCc1cnc(Nc3ccc(CO)cc3OC)nc1-2

HCID67076225

未命名化合物

PRODUCTS

生成物

HCID86653100

未命名化合物

收率 80%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of N-(2,6-diethylphenyl)-8-{[4-(hydroxymethyl)-2-methoxyphenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (50 mg, 0.097 mmol) in 1 ml of dry DCM, MnO2 (68 mg, 0.78 mmol) was added. The mixture was stirred at room temperature for 5 h, MnO2 filtered off and the solvent removed in vacuo affording the title compound in 80% yield.

WORKUP

后处理

filtrationMnO2 filtered off
customthe solvent removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-540a243717c34299ab91ccf74d79a2ed
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846701B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([CH2:34][OH:35])=[CH:30][C:29]=4[O:36][CH3:37])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:38])[N:15]=1)=[O:13])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][CH3:2])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([CH:34]=[O:35])=[CH:30][C:29]=4[O:36][CH3:37])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:38])[N:15]=1)=[O:13])[CH3:10]