HCID 67076225, compound → HCID 86653100, compound

HRID 81966Notes

Reaction equation

HRID 81966 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([CH2:34][OH:35])=[CH:30][C:29]=4[O:36][CH3:37])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:38])[N:15]=1)=[O:13])[CH3:2]>C(Cl)Cl.O=[Mn]=O>[CH2:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([CH2:1][CH3:2])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([CH:34]=[O:35])=[CH:30][C:29]=4[O:36][CH3:37])=[N:25][C:26]=3[C:17]=2[N:16]([CH3:38])[N:15]=1)=[O:13])[CH3:10]

Participants

4

Reactant 1

HCID 67076225HCID 67076225, compound

Product 1

HCID 86653100HCID 86653100, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of N-(2,6-diethylphenyl)-8-{[4-(hydroxymethyl)-2-methoxyphenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (50 mg, 0.097 mmol) in 1 ml of dry DCM, MnO2 (68 mg, 0.78 mmol) was added. The mixture was stirred at room temperature for 5 h, MnO2 filtered off and the solvent removed in vacuo affording the title compound in 80% yield.

Workup

  1. filtrationMnO2 filtered off
  2. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-540a243717c34299ab91ccf74d79a2ed
Source dataset
uspto-grants-2014_09
Patent number
US08846701B2

Reaction notes

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