Acetonitrile → HCID 178436230, compound

HRID 81971Notes

Reaction equation

HRID 81971 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][CH3:10])[C:4]=1[NH:11][C:12]([C:14]1[C:18]2[CH2:19][CH2:20][C:21]3[CH:22]=[N:23][C:24](I)=[N:25][C:26]=3[C:17]=2[N:16]([CH3:28])[N:15]=1)=[O:13])[CH3:2].[CH3:29][C:30]#[N:31]>>[NH2:31][C@H:30]1[CH2:1][CH2:3][C@H:4]([NH:11][C:24]2[N:23]=[CH:22][C:21]3[CH2:20][CH2:19][C:18]4[C:14]([C:12]([NH:11][C:4]5[C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=[CH:6][C:5]=5[CH2:9][CH3:10])=[O:13])=[N:15][N:16]([CH3:28])[C:17]=4[C:26]=3[N:25]=2)[CH2:5][CH2:29]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 86653101N-(2,6-diethylphenyl)-8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Product 1

HCID 178436230HCID 178436230, compound

Conditions

Temperature
110 °C

Procedure

N-(2,6-diethylphenyl)-8-iodo-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (500 mg, 1.01 mmol) was dissolved in CH3CN (3 ml) and treated with trans-1,4-diaminecyclohexane (346 mg, 303 mmol). The mixture was heated at 110° C. for 10 minutes under microwave irradiation. The solvent was removed under reduced pressure and the crude was purified by column chromatography to afford the title compound.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude was purified by column chromatography

Sources & evidence

ORD record
ord-a35ce91e47554129a75bad4efef177c3
Source dataset
uspto-grants-2014_09
Patent number
US08846701B2

Reaction notes

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