Triphenylphosphine → 4'-bromo-1'-(pyridin-2-ylmethyl)-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

HRID 819757Notes

Reaction equation

HRID 819757 reaction equation
[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][c:12]1[n:13][cH:14][cH:15][cH:16][cH:17]1)[C:5](=[O:18])[C:4]2([CH2:19][OH:20])[c:21]1[c:22]([OH:30])[cH:23][c:24]2[c:25]([cH:29]1)[CH2:26][CH2:27][O:28]2.[O:50]=[C:51]([O:52][CH:53]([CH3:54])[CH3:55])[N:56]=[N:57][C:58]([O:59][CH:60]([CH3:61])[CH3:62])=[O:63].[O:64]1[CH2:65][CH2:66][O:67][CH2:68][CH2:69]1.[c:31]1([P:32]([c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)[cH:45][cH:46][cH:47][cH:48][cH:49]1>>[Br:1][c:2]1[c:3]2[c:7]([cH:8][cH:9][cH:10]1)[N:6]([CH2:11][c:12]1[n:13][cH:14][cH:15][cH:16][cH:17]1)[C:5](=[O:18])[C:4]21[CH2:19][O:20][c:22]2[c:21]1[cH:29][c:25]1[c:24]([cH:23]2)[O:28][CH2:27][CH2:26]1

Participants

5

Reactant 4

HCID 11776TriphenylphosphineHCID 312751,4-DioxaneHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 588725124-bromo-3-(6-hydroxy-2,3-dihydro-1-benzofuran-5-yl)-3-(hydroxymethyl)-1-(Pyridin-2-ylmethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592634004'-bromo-1'-(pyridin-2-ylmethyl)-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-1f817693cb904571a0612c8eaf5639ba
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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