Acetic Acid → N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
Reaction equation
[CH3:29][CH2:30][OH:31].[CH3:34][C:35](=[O:36])[OH:37].[Cl:1][c:2]1[cH:3][c:4]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:23][CH:24]4[CH2:25][O:26][CH2:27][CH2:28]4)[c:17]([N+:20]([O-:21])=[O:22])[cH:18][c:19]23)[cH:5][cH:6][c:7]1[F:8].[Fe:33].[OH2:32]>>[Cl:1][c:2]1[cH:3][c:4]([NH:9][c:10]2[n:11][cH:12][n:13][c:14]3[cH:15][c:16]([O:23][CH:24]4[CH2:25][O:26][CH2:27][CH2:28]4)[c:17]([NH2:20])[cH:18][c:19]23)[cH:5][cH:6][c:7]1[F:8]Participants
6
Sources & evidence
- ORD record
- ord-f6ee40949f65402f90491155ca30460c
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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