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7-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amine → 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-(3,5-Dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amine | HCID 70980504 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-(1-methoxypropan-2-yl)quinoline-3,4-diamine | HCID 70980379 | 99% |
反応手順
7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N-(1-methoxypropan-2-yl)-3-nitroquinolin-4-amine (0.80 g, 2.070 mmol) was dissolved in EtOAc (120 ml) and hydrogenated using a flow hydrogenation apparatus (H Cube™, settings: full hydrogen, atmospheric pressure, 1 ml/min flow rate). The eluant was evaporated in vacuo to give the title compound as an orange gum (0.73 g, 99%). LCMS (formate) Rt 0.73 min, MH+ 357.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846709B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-99b2ec67f7b749ba882bc78e4e59ac4f |
| 出典メモ | uspto-grants-2014_09 |