Hydrochloric Acid → 2-[4-(2-Chloro-4-morpholin-4-ylfuro[3,2-d]pyrimidin-6-ylmethyl)piperazin-1-yl]isobutyramide

HRID 819931Notes

Reaction equation

HRID 819931 reaction equation
[C:33]([O:34][BH-:35]([O:36][C:37](=[O:38])[CH3:39])[O:40][C:41](=[O:42])[CH3:43])(=[O:44])[CH3:45].[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[O:12])[o:10]2.[ClH:19].[ClH:20].[N:21]1([C:27]([C:28](=[O:29])[NH2:30])([CH3:31])[CH3:32])[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]1.[Na+:46]>>[Cl:1][c:2]1[n:3][c:4]([N:13]2[CH2:14][CH2:15][O:16][CH2:17][CH2:18]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH2:11][N:24]1[CH2:23][CH2:22][N:21]([C:27]([C:28](=[O:29])[NH2:30])([CH3:31])[CH3:32])[CH2:26][CH2:25]1)[o:10]2

Participants

6

Reactant 5

HCID 313Hydrochloric Acid2×HCID 923Sodium ionHCID 2724942TriacetoxyborohydrideHCID 217488412-Methyl-2-(piperazin-1-yl)propanamideHCID 568337422-Chloro-4-morpholinofuro[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 596055422-[4-(2-Chloro-4-morpholin-4-ylfuro[3,2-d]pyrimidin-6-ylmethyl)piperazin-1-yl]isobutyramide

Sources & evidence

ORD record
ord-066c5273ddb849ca9bba76424f9e2f63
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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