Methanol → (+)-N4-(3,4-difluorophenyl)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-5-fluoro-2,4-pyrimidinediamine

HRID 819951Notes

Reaction equation

HRID 819951 reaction equation
[CH3:32][OH:33].[Cl:1][c:2]1[n:3][cH:4][c:5]([F:17])[c:6]([NH:8][c:9]2[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][cH:14]2)[n:7]1.[NH2:18][c:19]1[cH:20][cH:21][c:22]2[c:23]([cH:31]1)[CH2:24][CH:25]([C:27](=[O:28])[O:29][CH3:30])[O:26]2>>[c:2]1([NH:18][c:19]2[cH:20][cH:21][c:22]3[c:23]([cH:31]2)[CH2:24][CH:25]([C:27](=[O:28])[O:29][CH3:30])[O:26]3)[n:3][cH:4][c:5]([F:17])[c:6]([NH:8][c:9]2[cH:10][c:11]([F:16])[c:12]([F:15])[cH:13][cH:14]2)[n:7]1

Participants

4

Reactant 3

HCID 887MethanolHCID 22060823Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylateHCID 220610492-chloro-N4-(3,4-difluorophenyl)-5-fluoro-4-pyrimidineamine

Product 1

HCID 22060930(+)-N4-(3,4-difluorophenyl)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-5-fluoro-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-c0e4af761d354e78a40c9c3b18e7e6a3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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