HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Morpholinoethyl isothiocyanate → 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-N-[2-(4-morpholinyl)ethyl]-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Morpholinoethyl isothiocyanate | HCID 143957 | — |
| Reactant | 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-((tetrahydro-2H-pyran-4-yl)methyl)quinoline-3,4-diamine | HCID 70981155 | — |
| Product | 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-N-[2-(4-morpholinyl)ethyl]-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-imidazo[4,5-c]quinolin-2-amine | HCID 66571340 | 60% |
Reaction Steps
From 7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N4-((tetrahydro-2H-pyran-4-yl)methyl)quinoline-3,4-diamine (for a preparation see Intermediate 17) (70 mg) and 4-(2-isothiocyanatoethyl)morpholine (50 mg) to give the title compound as beige solid (57 mg, 60%). LCMS (formate) Rt 0.51 min, MH+ 521
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846709B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-dc4c1c9b045b4569aa8554fdb0ffeb35 |
| Source note | uspto-grants-2014_09 |