Dichloromethane → Trifluoroacetic acid

HRID 820107Notes

Reaction equation

HRID 820107 reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:12]2[n:13][o:14][c:15](-[c:17]3[cH:18][c:19]4[c:23]([cH:24][cH:25]3)[CH2:22][N:21]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:20]4)[n:16]2)[cH:5][cH:6][c:7]1[O:8][CH:9]([CH3:10])[CH3:11].[Cl:40][CH2:41][Cl:42].[F:33][C:34]([C:35](=[O:36])[OH:37])([F:38])[F:39]>>[Cl:1][c:2]1[cH:3][c:4](-[c:12]2[n:13][o:14][c:15](-[c:17]3[cH:18][c:19]4[c:23]([cH:24][cH:25]3)[CH2:22][NH:21][CH2:20]4)[n:16]2)[cH:5][cH:6][c:7]1[O:8][CH:9]([CH3:10])[CH3:11].[F:33][C:34]([C:35](=[O:36])[OH:37])([F:38])[F:39]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59556543Tert-butyl 5-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)isoindoline-2-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 595565583-(3-Chloro-4-isopropoxyphenyl)-5-(isoindolin-5-yl)-1,2,4-oxadiazole

Sources & evidence

ORD record
ord-35eb030380664966a1e5371b071e02d7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…