Sodium ion → 4-(4-Chlorophenyl)-1-[3-(4-fluorophenoxy)propyl]-4-piperidinol

HRID 820291Notes

Reaction equation

HRID 820291 reaction equation
[CH3:33][N:34]([CH3:35])[CH:36]=[O:37].[Cl:13][c:14]1[cH:15][cH:16][c:17]([C:20]2([OH:26])[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2)[cH:18][cH:19]1.[Cl:1][CH2:2][CH2:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([F:12])[cH:10][cH:11]1.[Na+:27].[Na+:28].[O-:29][C:30](=[O:31])[O-:32].[OH2:38]>>[CH2:2]([CH2:3][CH2:4][O:5][c:6]1[cH:7][cH:8][c:9]([F:12])[cH:10][cH:11]1)[N:23]1[CH2:22][CH2:21][C:20]([c:17]2[cH:16][cH:15][c:14]([Cl:13])[cH:19][cH:18]2)([OH:26])[CH2:25][CH2:24]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 743911-(3-Chloropropoxy)-4-fluorobenzene

Product 1

HCID 215277714-(4-Chlorophenyl)-1-[3-(4-fluorophenoxy)propyl]-4-piperidinol

Sources & evidence

ORD record
ord-9cbe406be5ba46ce967c730e8623ef94
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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