8-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)--4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 8-Chloro-7-[3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluorocyclopropyl)-4-oxoquinoline-3-carboxylic acid

HRID 820379Notes

Reaction equation

HRID 820379 reaction equation
[CH:22]1([NH:25][CH2:26][CH:27]2[CH2:28][NH:29][CH2:30][CH:31]2[F:32])[CH2:23][CH2:24]1.[Cl:1][c:2]1[c:3]([F:21])[c:4]([F:20])[cH:5][c:6]2[c:7](=[O:19])[c:8]([C:16](=[O:17])[OH:18])[cH:9][n:10]([CH:12]3[CH:13]([F:15])[CH2:14]3)[c:11]12>>[Cl:1][c:2]1[c:3]([N:29]2[CH2:28][CH:27]([CH2:26][NH:25][CH:22]3[CH2:23][CH2:24]3)[CH:31]([F:32])[CH2:30]2)[c:4]([F:20])[cH:5][c:6]2[c:7](=[O:19])[c:8]([C:16](=[O:17])[OH:18])[cH:9][n:10]([CH:12]3[CH:13]([F:15])[CH2:14]3)[c:11]12

Participants

3

Reactant 2

HCID 193650428-Chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)--4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 230620733-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4S)-(9CI)

Product 1

HCID 231256598-Chloro-7-[3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-1-(2-fluorocyclopropyl)-4-oxoquinoline-3-carboxylic acid

Sources & evidence

ORD record
ord-b43962a901484df6ada6a6aa57cdf5df
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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