Toluene → N-[4-fluoro-3-(trifluoromethyl)benzyl]-N'-(3-methyl-5-isoquinolinyl)urea

HRID 820668Notes

Reaction equation

HRID 820668 reaction equation
[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[CH:18]([N:19]([CH2:20][CH3:21])[CH:22]([CH3:23])[CH3:24])([CH3:25])[CH3:26].[Cl:14][C:15]([Cl:16])=[O:17].[F:1][c:2]1[c:3]([C:10]([F:11])([F:12])[F:13])[cH:4][c:5]([CH2:6][NH2:7])[cH:8][cH:9]1.[NH2:27][c:28]1[c:29]2[cH:30][c:31]([CH3:38])[n:32][cH:33][c:34]2[cH:35][cH:36][cH:37]1>>[F:1][c:2]1[c:3]([C:10]([F:11])([F:12])[F:13])[cH:4][c:5]([CH2:6][NH:7][C:15](=[O:17])[NH:27][c:28]2[c:29]3[cH:30][c:31]([CH3:38])[n:32][cH:33][c:34]3[cH:35][cH:36][cH:37]2)[cH:8][cH:9]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 6371PhosgeneHCID 81531DiisopropylethylamineHCID 522270[4-Fluoro-3-(trifluoromethyl)phenyl]methanamineHCID 122120553-Methylisoquinolin-5-amine

Product 1

HCID 22032629N-[4-fluoro-3-(trifluoromethyl)benzyl]-N'-(3-methyl-5-isoquinolinyl)urea

Sources & evidence

ORD record
ord-931c2c65b6954dd0bcc065e0f10fa856
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…