Hydrochloric Acid → (3-Chloro-isoquinolin-1-yl)-[1-(2,6-diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-yl]-amine

HRID 820841Notes

Reaction equation

HRID 820841 reaction equation
[CH2:49]([CH3:50])[O:51][c:52]1[c:53](-[c:63]2[cH:64][cH:65][c:66]([F:69])[cH:67][cH:68]2)[c:54]([O:60][CH2:61][CH3:62])[cH:55][c:56]([CH:58]=[O:59])[cH:57]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([NH:11][c:12]3[cH:13][c:14]([NH:15][C:16](=[O:17])[CH3:18])[cH:19][cH:20][cH:21]3)[CH2:22][CH2:23]2)[cH:24][c:25]1[O:26][CH2:27][CH3:28].[Cl:31][c:32]1[n:33][c:34]([NH:42][CH:43]2[CH2:44][CH2:45][NH:46][CH2:47][CH2:48]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]2[cH:41]1.[ClH:29].[ClH:30]>>[Cl:31][c:32]1[n:33][c:34]([NH:42][CH:43]2[CH2:44][CH2:45][N:46]([CH2:58][c:56]3[cH:55][c:54]([O:60][CH2:61][CH3:62])[c:53](-[c:63]4[cH:64][cH:65][c:66]([F:69])[cH:67][cH:68]4)[c:52]([O:51][CH2:49][CH3:50])[cH:57]3)[CH2:47][CH2:48]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]2[cH:41]1

Participants

5

Reactant 4

HCID 313Hydrochloric Acid2×HCID 24854968N-{3-[1-(4-Chloro-3-ethoxy-benzyl)-piperidin-4-ylamino]-phenyl}-acetamideHCID 593830993-chloro-N-piperidin-4-ylisoquinolin-1-amineHCID 593831002,6-Diethoxy-4'-fluoro-biphenyl-4-carbaldehyde

Product 1

HCID 86618560(3-Chloro-isoquinolin-1-yl)-[1-(2,6-diethoxy-4'-fluoro-biphenyl-4-ylmethyl)-piperidin-4-yl]-amine

Sources & evidence

ORD record
ord-5e303ecd079c458ea2774f716d04a450
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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