Water → 2-Cyclohexyl-1-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-ethanone

HRID 820963Notes

Reaction equation

HRID 820963 reaction equation
[CH3:8][S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][c:15]([O:16][c:17]2[c:18]3[c:19]([n:20][cH:21][n:22]2)[n:23]([CH:26]2[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[n:24][cH:25]3)[cH:32][cH:33]1.[CH:34]1([CH2:40][C:41](=[O:42])[Cl:43])[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[OH2:44]>>[CH3:8][S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][c:15]([O:16][c:17]2[c:18]3[c:19]([n:20][cH:21][n:22]2)[n:23]([CH:26]2[CH2:27][CH2:28][N:29]([C:41]([CH2:40][CH:34]4[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]4)=[O:42])[CH2:30][CH2:31]2)[n:24][cH:25]3)[cH:32][cH:33]1

Participants

5

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 2757989Cyclohexylacetyl chlorideHCID 579649614-(4-Methylsulfonylphenoxy)-1-piperidin-4-ylpyrazolo[5,4-d]pyrimidine

Product 1

HCID 579650282-Cyclohexyl-1-{4-[4-(4-methanesulfonyl-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-ethanone

Sources & evidence

ORD record
ord-4c47728b417849c6a220ad718d52cb94
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…