HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → racemic Methyl 2-{5-[(5-{[(4-chlorophenyl)acetyl]amino}pyridin-3-yl)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 2-bromopropionate | HCID 95576 | — |
| Reactant | 2-(4-chlorophenyl)-N-[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylcarbonyl)pyridin-3-yl]acetamide | HCID 70817645 | — |
| Product | racemic Methyl 2-{5-[(5-{[(4-chlorophenyl)acetyl]amino}pyridin-3-yl)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}propanoate | HCID 70817494 | — |
Reaction Steps
The title compound was prepared according to the method described for Example 229 using 2-(4-chlorophenyl)-N-[5-(7H-pyrrolo[2,3-d]pyrimidin-5-ylcarbonyl)pyridin-3-yl]acetamide (Example 308), methyl 2-bromopropionate and cesium carbonate. Purified using preparative HPLC (method 1) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846698B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9a4f5f942894436a8a41558eb19d246d |
| Source note | uspto-grants-2014_09 |