(2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone → HCID 70817726, compound

HRID 82136Notes

Reaction equation

HRID 82136 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]([C:13]3[CH:14]=[N:15][CH:16]=[C:17]([NH2:19])[CH:18]=3)=[O:12])=[CH:9][N:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:6]=2[N:7]=1.[CH:24]1([C:27]2[CH:28]=[N:29][N:30]([CH2:32][C:33](O)=[O:34])[CH:31]=2)[CH2:26][CH2:25]1>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([C:11]([C:13]3[CH:18]=[C:17]([NH:19][C:33](=[O:34])[CH2:32][N:30]4[CH:31]=[C:27]([CH:24]5[CH2:25][CH2:26]5)[CH:28]=[N:29]4)[CH:16]=[N:15][CH:14]=3)=[O:12])=[CH:9][N:8]([C:20]([CH3:23])([CH3:22])[CH3:21])[C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 70817234(2-amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanoneHCID 847316142-(4-Cyclopropyl-1H-pyrazol-1-yl)acetic acid

Product 1

HCID 70817726HCID 70817726, compound

Procedure

The title compound was prepared according to the method described for Example 1 using (2-Amino-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(5-amino-pyridin-3-yl)-methanone (see Preparation 65) and (4-cyclopropyl-pyrazol-1-yl)-acetic acid to afford the title compound as a pale yellow solid in 16% yield, 12 mg. LCMS (System 10): Rt=2.80 min; m/z 459 [M+H]+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ebdda26fdef14cc1a3a12c7dc3c415bf
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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